Calcium Indicators
Cell-based calcium flux assays are widely used in high throughput screening (HTS) to determine agonist-stimulated and antagonist-inhibited signaling through G protein-coupled receptors (GPCRs), a large family of integral membrane proteins and an important target class in drug discovery. Accurate measurements of intracellular calcium concentration and mobilization allows for a more comprehensive understanding of calcium regulated signaling pathways, cellular functions and pathological processes.AAT Bioquest has developed the largest collection of calcium indicators, including Fluo-8® , Cal-520®, and Calbryte™ calcium indicators, as well as, calcium flux assays to track calcium mobilization with intense fluorescent signals and in a variety of wavelength options ranging from ultraviolet to infrared. |