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Borrelia VlsE1/pepC10 IgG/IgM ELISA kit

Lyme disease is the most common tick-borne disease in the Northern Hemisphere, and is caused by infection with Borrelia, a group of spirochetal bacteria commonly transferred from tick bites. Serological evidence of exposure is an important aid in the diagnosis of Lyme disease, and the development of recombinant and synthetic antigens has brought about second generation assays with improved clinical specificity and sensitivity1.
 
Two antigens are better than one.

• Why VlsE1? The VlsE1 protein has several  
   immunodominant epitopes, including C6,
   which can improve clinical diagnostic
   sensitivity
• Why pepC10? pepC10 is a peptide derived
   from Outer Surface Protein C (OspC), which is
   the immunodominant antigen of the IgM
   response in Lyme disease. Detection of IgM
   antibodies to pepC10 can be especially helpful
   in the diagnosis of acute Lyme disease2.
• The VlsE1/pepC10 is ideal for serodiagnosis of
   major infectious European Lyme disease (B.
   afzelii, B. garinii, B burgdorferi ). (See Figure 1)3

Product Features
• Achieves superior clinical sensitivity and specificity by testing two antigens, VlsE1 + pepC10, in the same well.
• Yields excellent assay reproducibility using highly purified and specific antigens.
• Adapts to your workflow with flexibility for manual, semi-automated, or fully-automated operation.

Ordering Information
 Catalog No:  Product Description
 3Z9661  Borrelia VlsE1/pepC10 IgG/IgM Test System (96 tests)

More information: ZEUS ELISA™ Borrelia VlsE1/pepC10 IgG/IgM Test System Flyer

1. Wilske, B., et al. 2007. Microbiological and serological diagnosis of Lyme borreliosis. FEMS Immunol Med Microbiol 49:13-21.
2. Bacon, R., et al. 2003. Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent assay Using Recombinant  VIsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing using Whole-Cell Lysate. J Infect Dis. 187:1187-1199.
3. Dibernardo, A., et al. Laboratory evaluation of the performance of the ZEUS PEPC10/VIsE ELISA to detect antibodies to members of the European genospecies of Borrelia burgdorferi sensu late. Public Health Ontario.

Info ZEUS Scientific

Infectious disease and autoimmune diagnostics

ZEUS Scientific offers flexible solutions for autoimmune and infectious disease testing across three platforms: ZEUS ELISA™, AtheNA Multi-Lyte®, and ZEUS IFA™. ZEUS has designed its products with common reagents and common protocols that can help increase efficiency and streamline workflow in any lab. 

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