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CRISPR/Cas9


The discovery of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and Cas9 (CRISPR associated system or CRISPR associated protein 9 nuclease) found in bacteria to work as a defense mechanism against foreign DNA, has proven to be an invaluable tool to target and modify a genetic sequence in gene editing and genome engineering applications. The system, known as CRISPR/Cas9, allows for sequence-specific cleavage of a targeted genomic locus by delivering the RNA-guided nuclease (Cas9) and appropriate guide RNAs (gRNA) into a cell. In addition, Protospacer Adjacent Motif (PAM) sequence immediately following the specificity sequence is necessary for successful binding of the Cas9 nuclease.

Epigentek offers a monoclonal CRISPR/Cas9 antibody, ideal for immunofluorescence applications, as well as a polyclonal CRISPR/Cas9 antibody, ideal for immunoprecipitation applications.

Anti-Cas9 antibodies can be used for:
 

- Detection of CRISPR/Cas9 expression in target cells by WB, IF, IP or ELISA to confirm whether gRNA and Cas9 vectors are
  successfully transfected
- Detection of genome-wide off- and on-target effects of CRISPR/Cas9 on the specific gene sites by Cas9 ChIP-seq in CRISPR
  genome editing


View monoclonal anti-Cas9
View polyclonal anti-Cas9
 

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Info Epigentek

Epigenetic kits, antibodies and reagents for use in DNA methylation, histone modification, and chromatin studies.


Epigentek is the leading developer and provider of innovative technologies and products for epigenetic-related research. Founded in 2005, the company has since developed a comprehensive portfolio of proprietary products to provide complete and systematic solutions for epigenetics-related research and drug discovery.
Epigentek products are used all around the world by esteemed academia, leading pharmaceuticals, and cutting-edge biotechnology companies. These unique products are specifically designed to make assays much simpler, faster, more convenient, and highly more efficient than currently used methods.

For more information:
http://www.epigentek.com

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