Biosynex

Biosynex

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IMMUNOQUICK®

Acute gastroenteritis continues to be a major cause of morbidity and mortality throughout the world with around 700 million annual cases in children under five years and a mortality rate estimated to be 3-5 million cases per year.

Rotavirus, Adenovirus and Norovirus

Although bacteria, viral agents and parasites could be responsible for gastroenteritis, many studies have illustrated that viral agents are the most important factors.

Rotavirus, Norovirus and Adenovirus have been reported as the common viral pathogens of acute gastroenteritis in children. The main symptoms of viral gastroenteritis are watery diarrhea and vomiting.
The affected person may also have headache, fever and abdominal cramps ("stomach ache").

Rotavirus is transmitted via the feco-oral route and, following establishment in the small intestine, results in nutrient malabsorption. The clinical spectrum of acute rotavirus gastroenteritis ranges from a self-limited watery diarrhea illness accompanied with nausea, anorexia and mild vomiting or fever, to sever dehydration resulting in hospitalization or even death. Although rotavirus primarily infects children, it could cause a mild disease in adults.

Adenovirus infection is mostly seen in pediatrics up to 2 years old.

Norovirus is a major cause of gastrointestinal illness in closed and crowded environments, such as hospitals, nursing homes and cruise ships. Nororvirus is commonly spread through food or water contaminated by fecal matter during preparation.



Clostridium difficile

Clostridium difficile is the most commonly identified cause if nosocomial diarrhea in adults. Clostridum difficile causes most cases of infectious diarrhea acquired in hospitalized adults, including pseudo-membranous colitis (PC). PC is a severe inflammation of the colon which can be life threatening, especially among the eldery. PC due to C. difficile infection is associated with toxigenic strains (toxin A, a tisseu-damaging enterotoxin and toxin B, a cytotoxin).
The diagnosis can be achieved by detecting in stool samples whether glutamate dehydrogenase (GDH) is present or not (its presence indicates the presence of Clostridium difficile), then by running the Tox A/B test to determine whether C. difficile in the sample is pathogenic or not.

 

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Info Biosynex

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BIOSYNEX is a french diagnostic company located in Strasbourg, one of the European capital cities at the crossroads of France and Germany. Their Research and Development laboratory and our state of the art manufactiring facility are continuously dedicated to meet new needs of the medical sector.

BIOSYNEX is specialized in :
• Obstetrics
• Drugs of abuse
• Infectious diseases
• Emergency markers
• Cancer markers

For more information:
http://www.biosynex.com

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