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p63, clone 4A4
In addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.
p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.

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p63 Antibody Immunohistochemistry on a FFPE Basal Cell Carcinoma Tissue

 
BAP1, clone BSB-109
BAP1 or BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene.
In cancer, BAP1 can function both as a Tumor suppressor and as a metastasis suppressor. Exome sequencing identified inactivating mutations in BAP1 in 47% of Uveal melanomas, and BAP1 mutation have been found to be strongly associated with metastasis.

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BAP1 Antibody Immunohistochemistry on a FFPE Mesothelioma Tissue

 
SMAD4, clone RBT-SMAD4
SMAD4, also known as DPC4 or SMAD family member n°4, is a protein involved in cell signaling in mammals.
SMAD4 serves as a mediator between extracellular growth factors from the TGFβ family and genes inside the cell nucleus. SMAD4 is also defined as a signal transducer.
The functional SMAD4 participates in the regulation of the TGF-β signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). When the structure of SMAD4 is altered, expression of the genes involved in cell growth is no longer regulated and cell proliferation can go on without any inhibition. The important number of cell divisions leads to the forming of tumors and then to multiploid colorectal cancer and pancreatic carcinoma

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SMAD4 Antibody Immunohistochemistry on a FFPE Pancreatic Cancer Tissue

Info BioSB

Bio SB produces Rabbit Monoclonals and various other products for Immunohistochemistry (IHC) and Immunocytochemistry (ICC) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology and Immunology. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP and ISO 13485:2003 standards. These guidelines enable Bio SB to produce an IVD product that meets the highest in vitro diagnostic standards. 

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